To facilitate overall readability of the main manuscript text we chose to illustrate the univariable analyses by categorical “yes or no” tranexamic acid use instead of the more detailed categorization by dosage; the latter tables are provided in supplementary appendices 3 to 5.Multilevel logistic regression analysisWe built separate multilevel multivariable logistic regression models to measure the association between use of tranexamic acid and the binary outcome variables. To account for correlation of patients within hospitals we included a random intercept term that varies at the level of each hospital. All hospitals (clusters) had sufficient patients (n>30) according to previously recommended sample sizes for this type of model to reduce bias.14 We adjusted models using all available demographic, healthcare related, procedure related, and comorbidity variables that were significant (P15) in the univariable analysis.

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